Bacteria have a wall around the outside of their cells that gives them shape and is a source of strength. Antibiotics like penicillin kill bacteria by preventing building of the wall. In order for a cell to grow, it has to divide and expand. If you completely block the breakdown of the wall, it is like it is trapped in a prison, and can’t expand or grow. The newly-found corbomycin and the lesser-known complestatin have a never-before-seen way to kill bacteria, which is achieved by blocking the function of the bacterial cell wall. The discovery comes from a family of antibiotics called glycopeptides that are produced by soil bacteria. This approach can be applied to other antibiotics and help us discover new ones with different mechanisms of action. Thanks to these investigations the arsenal of drugs against microbes can make a leap that takes us from the trenches to the enemy lines.